Author: Medical Team
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download ArticleBACKGROUND
In a new study published in SKIN - JOURNAL OF CUTANEOUS MEDICINE, researchers found out that Benzoyl peroxide (E-BPO) 5% encapsulated with silica gel is clinically effective for the treatment of inflammatory lesion occurring in rosacea. This first-ever encapsulated formulation of benzoyl peroxide first received approval from FDA on 25 April, 2022.
ABOUT ROSACEA
Rosacea is a long-term inflammatory skin disorder characterized by facial erythema, flushing, papules, pustules, phymas, and telangiectasias. It primarily affects the cheeks, nose, chin, forehead, and eyes. The occurrence of rosacea is more prevalent in people with fair skin from celtic and northern European descent. One study reported that rosacea account for almost 0.5% of all dermatology consultations in India indicating its commonness than what is perceived for Indian population.
Current treatment options for rosacea include lasers, OTC products containing azelaic acid and sulfur, however these treatments lack efficacy in the treatment of inflammatory nodules associated with rosacea and there is an issue of lack of patient compliance with the use of technology like laser.
In such scenario Encapsulated benzoyl peroxide is a novel product with better efficacy and tolerability profile, and can be used in patients that are not satisfied with the other treatment options.
WHAT MAKES ENCAPSULATED BENZOYL PEROXIDE BETTER?
Microencapsulation creates a shell of silicon dioxide between Benzoyl peroxide & skin, and thus controls the release of benzoyl peroxide to improve its tolerability. This allows the use of benzoyl peroxide in more sensitive and dry skin.
Microencapsulation |
STUDY CHARACTERISTICS
Investigator Global Assessment (IGA) scale
|
|
Grade |
Description |
0 - Clear |
Skin clear of inflammatory papules or pustules |
1 - Almost Clear |
Presence of very few small papules/ pustules and very mild dull erythema |
2 - Mild |
Presence of few small papules / pustules and very mild dull erythema |
3 - Moderate |
Several to many small or larger papules or pustules and moderate light to bright red erythema are present |
4 - Severe |
Numerous small and/or larger papules or pustules and severe erythema that is bright red to deep red are present |
RESULTS
CONCLUSION
Treatment with encapsulated benzoyl peroxide (5%) is superior to vehicle in the treatment of inflammatory lesions of rosacea. People with rosacea experience a significant burden of this disease and have diminished quality of life. Hence, approval of such a novel formulation is an important advancement for the people living with rosacea worldwide.
REFERENCE